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Assessment and Treatment of Depression: A Clinical Look at the Current Controversies

Mark Zimmerman, MD, discusses controversies related to categorizing severity and identifying optimal treatment of depression.

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Patients With Schizophrenia Have Difficulty Identifying Auditory Emotion

Patients with schizophrenia have difficulty identifying emotions from the acoustics of a speaker’s voice.

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Increased Adherence With Paliperidone Once Every 3 Months in Schizophrenia

Transition from a once-monthly formulation of a long-acting, injectable paliperidone palmitate to a once-every-3-month formulation treatment regimen in patients with schizophrenia demonstrated increased adherence to antipsychotic medication.

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Brexpiprazole Appears Safe, Effective in Schizophrenia During Severe Psychotic Episodes

At 6 weeks of treatment, severely ill patients treated with adjunctive brexpiprazole had a greater reduction in PANSS total scores and CGI-S scores compared with those receiving placebo.

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In Study of Veterans, Therapy Most Significant Predictor of PTSD Recovery

Patients with PTSD should consider concurrent treatment with evidence-based psychotherapy to maximize their chances for meaningful improvement.

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Mortality Rate for Bipolar Disorder Has Increased in Denmark Since the 1990s

Younger individuals may be more at risk for death by suicide, and in older patients, elevated levels of metabolic syndrome may lead to higher rates of death from heart disease.

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Schizophrenia Therapy Adherence Tied to Patients’ Beliefs

Given the substantial burden of nonadherence to therapy in patients with schizophrenia, new interventions for compliance are critical.

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Repeated-Dose Ketamine for Reducing Suicidal Ideation in Treatment-Resistant Depression

Investigators sought to examine the short- and long-term antidepressant and antisuicidal effects of repeated-dose ketamine augmentation in patients with treatment-resistant depression.

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High Psychopathy Scores Associated With Lower Self-Reported Empathy Levels

The researchers hypothesize that empathy induction activities could increase prosocial behavior among violent offenders.

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Long-term Healthy Diet Associated With Greater Hippocampal Volumes

This study presents strong evidence for an association between a healthy diet and hippocampal volumes.

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Little to No Association Found Between Physician Performance and Medical School Ranking

Researchers found a limited association between the ranking of a physician’s medical school and patient mortality or readmission rates.

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Certain Lots of Quillivant XR May Potentially Have Quality/Efficacy Issues

Quillivant XR, a central nervous system stimulant, is indicated to treat ADHD in patients aged 6 years and older.

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Mindfulness-Based Stress Reduction Effective for Veterans With PTSD

This research supports the use of mindfulness-based stress reduction as a treatment method for veterans with PTSD.

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Latent Structure of Negative Symptoms in Schizophrenia Best Conceptualized by 5-Domain Model

Existing 2-dimensional models are likely not sufficient to capture the complexity of negative symptoms in schizophrenia.

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Shame Drives Suicidal Ideation Among Veterans With Post-traumatic Stress Disorder

The authors argue that these findings suggest that reducing shame among veterans with post-traumatic stress disorder may reduce the risk for suicide.