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Aberrant Epstein-Barr Virus Response Associated With Schizophrenia

Investigators confirmed that people with schizophrenia have higher levels of antibodies to some but not all Epstein-Barr virus proteins, which indicates an aberrant response to Epstein-Barr virus infection that may be a factor in the immunopathology of schizophrenia and related disorders.

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Pharmacogenomic-Guided Care May Improve Clinical Outcomes in MDD

Weighted and combined multi-gene pharmacogenomic testing significantly increased clinical response and remission rates for patients with major depressive disorder.

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Increased Risk for Death in Youths Taking High-Dose Antipsychotics

Researchers retrospectively reviewed data regarding children and youths who were beginning treatment with antipsychotic vs control medications to assess their risks for unexpected death.

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Prenatal Exposure to Air Pollutants Linked With Increased Incidence of Autism

Researchers investigated a potential link between increased risk for autism and prenatal exposure to air pollution.

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Comorbid Mental Disorder Prevalence Higher in Pulmonary Arterial Hypertension

People with pulmonary arterial hypertension display higher levels of depression and anxiety than previously estimated by healthcare workers.

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Part 2: Adolescent Tech Use & Mental Health: Expert Perspective

For part 2 of this article, Psychiatry Advisor interviewed Dr Brenda L Curtis, whose research focuses on “big data” generated from social networking sites, technology-based interventions for substance use disorders and related issues, and Internet research ethics.

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Mood Disorder, Obesity Associated With Poorer Physical, Mental Outcomes

The co-occurrence of obesity and mood disorders increases the risk for physical comorbidities, poor mental health and psychological well-being, and less healthy behaviors.

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Cognitive Behavior Therapy for Social Activation in Schizophrenia Not Cost-Effective

Although treatment as usual for psychosis is guideline-congruent and well implemented, there appears to be no added value for adjunct cognitive behavioral therapy for social activation, according to the results of a study from the Netherlands.

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Cognitive Ability May Help Differentiate OCD From Generalized Anxiety in Children

A study compared participants with clear diagnoses of either generalized anxiety disorder or obsessive-compulsive disorder with each other, as well as with controls, in order to identify cognitive differences between both groups.

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Local Interest

WHAT’S UP DOC? Potential of gene therapy still to be realized

Q: I have read about gene therapy on and off for years, but not much has seemed to happen lately. What is the future of gene therapy?A: First, a bit of a disclaimer: some of my earliest research in medicine was in the field of gene therapy (for example, I …

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Local Interest

SENIOR Q&A: Plan for winter power outages at mom’s house

Q: I am worried about my mother and the inside temperature of her house. She likes to keep the heat up to at least 78 degrees. As we approach the coldest temperatures in winter I worry that if the power goes out or her furnace stops working she will get …

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Trauma, Stress, and More Linked to Depressive Disorders in College Freshmen

As major depressive disorder is common among college students, researchers sought to determine factors that contribute to this condition, particularly among college freshmen.

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Examining Predictors of OCD Treatment Response Trajectory

Intensive residential treatment was found to be effective in reducing the symptoms of obsessive-compulsive disorder, although different response trajectories were observed.

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The Importance of Cerebral Blood Flow in Late-Life Depression

Investigators used neuroimaging to examine relationships between late-life depression, cerebral blood flow, and white matter hyperintensities.

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PTSD, Depressive Symptoms Mediate Relationship Between Insomnia and Risk for Suicidal Behavior

Symptoms of depression and PTSD may be increased in veterans with insomnia, which may be associated with an increased risk for suicidal behavior.

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Valacyclovir Fails to Treat Herpes Simplex Virus-Type 1 in Schizophrenia

Valacyclovir was not efficacious in the study, perhaps because HSV-1 was in the dormant, nonactivated state and therefore non-responsive to valacyclovir effects.

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FDA to Review Treatment for Jet Lag Disorder

In the Phase 3 JET8 study (N=318), patients underwent a circadian challenge of 8 hours in advance to their usual bedtime.

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